| Player | Mat | Balls | Runs | Wkts | Best | Avge | Econ | SR | 4 Wkt | 5 Wkt |
| Shaun Pollock | 303 | 15712 | 9631 | 393 | 6/35 | 24.50 | 3.67 | 39.97 | 12 | 5 |
| Allan Donald | 164 | 8561 | 5926 | 272 | 6/23 | 21.78 | 4.15 | 31.47 | 11 | 2 |
| Jacques Kallis | 321 | 10636 | 8558 | 270 | 5/30 | 31.69 | 4.82 | 39.39 | 2 | 2 |
| Makhaya Ntini | 173 | 8687 | 6559 | 266 | 6/22 | 24.65 | 4.53 | 32.65 | 8 | 4 |
| Lance Klusener | 171 | 7336 | 5751 | 192 | 6/49 | 29.95 | 4.70 | 38.20 | 1 | 6 |
| Hansie Cronje | 188 | 5357 | 3966 | 114 | 5/32 | 34.78 | 4.44 | 46.99 | 1 | 1 |
| Andre Nel | 79 | 3801 | 2935 | 106 | 5/45 | 27.68 | 4.63 | 35.85 | 3 | 1 |
| Morne Morkel | 60 | 2959 | 2413 | 104 | 5/38 | 23.20 | 4.89 | 28.45 | 6 | 1 |
| Charl Langeveldt | 72 | 3489 | 2962 | 100 | 5/39 | 29.62 | 5.09 | 34.89 | 1 | 2 |
| Dale Steyn | 72 | 3579 | 2933 | 100 | 5/50 | 29.33 | 4.91 | 35.79 | 3 | 1 |
| Nicky Boje | 115 | 4541 | 3415 | 96 | 5/21 | 35.57 | 4.51 | 47.30 | 2 | 1 |
| Andrew Hall | 88 | 3341 | 2515 | 95 | 5/18 | 26.47 | 4.51 | 35.16 | 3 | 1 |
| Fanie de Villiers | 83 | 4422 | 2636 | 95 | 4/27 | 27.74 | 3.57 | 46.54 | 2 | 0 |
| Craig Matthews | 56 | 3003 | 1975 | 79 | 4/10 | 25.00 | 3.94 | 38.01 | 3 | 0 |
| Lonwabo Tsotsobe | 43 | 2105 | 1683 | 73 | 4/22 | 23.05 | 4.79 | 28.83 | 5 | 0 |
| Johan Botha | 78 | 3823 | 2916 | 72 | 4/19 | 40.50 | 4.57 | 53.09 | 1 | 0 |
| Pat Symcox | 80 | 3991 | 2762 | 72 | 4/28 | 38.36 | 4.15 | 55.43 | 1 | 0 |
| Brian McMillan | 78 | 3623 | 2589 | 70 | 4/32 | 36.98 | 4.28 | 51.75 | 1 | 0 |
| Robin Peterson | 67 | 2805 | 2230 | 63 | 4/12 | 35.39 | 4.77 | 44.52 | 1 | 0 |
| Roger Telemachus | 37 | 1918 | 1565 | 56 | 4/43 | 27.94 | 4.89 | 34.25 | 1 | 0 |
| Albie Morkel | 58 | 2073 | 1899 | 50 | 4/29 | 37.98 | 5.49 | 41.46 | 2 | 0 |
| Steve Elworthy | 39 | 1702 | 1235 | 44 | 3/17 | 28.06 | 4.35 | 38.68 | 0 | 0 |
| Richard Snell | 42 | 2095 | 1574 | 44 | 5/40 | 35.77 | 4.50 | 47.61 | 2 | 1 |
