| Player | Total Sixes | Career Runs | Team |
| Shahid Afridi | 308 | 7201 | Pakistan / ICC World XI |
| Sanath Jayasuriya | 270 | 13430 | Sri Lanka / Asian XI |
| Chris Gayle | 194 | 8481 | West Indies / ICC World XI |
| Sachin Tendulkar | 192 | 18426 | India |
| Sourav Ganguly | 190 | 11363 | India / Asian XI |
| Ricky Ponting | 162 | 13704 | Australia / ICC World XI |
| Chris Cairns | 153 | 4950 | New Zealand / ICC World XI |
| MS Dhoni | 152 | 7286 | India |
| Adam Gilchrist | 149 | 9619 | Australia / ICC World XI |
| Brendon McCullum | 147 | 4926 | New Zealand |
| Yuvraj Singh | 145 | 8211 | India |
| Inzamam-ul-Haq | 144 | 11739 | Pakistan / Asian XI |
| Virender Sehwag | 136 | 8273 | India / Asian XI |
| Jacques Kallis | 136 | 11498 | South Africa / ICC World XI |
| Brian Lara | 133 | 10405 | West Indies / ICC World XI |
| Herschelle Gibbs | 128 | 8094 | South Africa |
| Sir Viv Richards | 126 | 6721 | West Indies |
| Abdul Razzaq | 124 | 5080 | Pakistan / Asian XI |
| Wasim Akram | 121 | 3717 | Pakistan |
| Andrew Symonds | 103 | 5088 | Australia |
| Aravinda de Silva | 102 | 9284 | Sri Lanka |
| Shane Watson | 101 | 4761 | Australia |
| Saeed Anwar | 97 | 8823 | Pakistan |
| Ross Taylor | 96 | 3743 | New Zealand |
| Hansie Cronje | 94 | 5565 | South Africa |
| Andrew Flintoff | 93 | 3394 | England / ICC World XI |
| AB de Villiers | 92 | 5612 | South Africa / Africa XI |
| Mohammad Yousuf | 90 | 9720 | Pakistan / Asian XI |
| Ijaz Ahmed | 87 | 6564 | Pakistan |
| Suresh Raina | 87 | 4077 | India |
| Matthew Hayden | 87 | 6133 | Australia / ICC World XI |
| Nathan Astle | 86 | 7090 | New Zealand |
| Shivnarine Chanderpaul | 85 | 8778 | West Indies |
| Ajay Jadeja | 85 | 5359 | India |
| Kieron Pollard | 84 | 1782 | West Indies |
| Craig McMillan | 84 | 4707 | New Zealand |
| Mark Boucher | 83 | 4686 | South Africa / Africa XI |
| Elton Chigumbura | 82 | 2837 | Zimbabwe |
| Gordon Greenidge | 81 | 5134 | West Indies |
| Jacob Oram | 81 | 2434 | New Zealand |
| Michael Hussey | 80 | 5442 | Australia |
| Mohammad Azharuddin | 77 | 9378 | India |
| Lance Klusener | 76 | 3576 | South Africa |
| Ricardo Powell | 75 | 2085 | West Indies |
| Kevin Pietersen | 75 | 4369 | England / ICC World XI |
| Paul Collingwood | 74 | 5092 | England |
| Steve Waugh | 68 | 7569 | Australia |
| Scott Styris | 68 | 4483 | New Zealand |
| Kapil Dev | 67 | 3783 | India |
| Carl Hooper | 65 | 5761 | West Indies |
