| Player | Total Sixes | Career Runs | Team |
| Adam Gilchrist | 100 | 5570 | Australia / ICC World XI |
| Brian Lara | 88 | 11953 | West Indies / ICC World XI |
| Chris Cairns | 87 | 3320 | New Zealand / ICC World XI |
| Sir Viv Richards | 84 | 8540 | West Indies |
| Matthew Hayden | 80 | 8242 | Australia / ICC World XI |
| Andrew Flintoff | 77 | 3381 | England / ICC World XI |
| Clive Lloyd | 70 | 7515 | West Indies |
| Gordon Greenidge | 67 | 7558 | West Indies |
| Ian Botham | 67 | 5200 | England |
| Carl Hooper | 63 | 5762 | West Indies |
| Jacques Kallis | 62 | 9477 | South Africa / ICC World XI |
| Kapil Dev | 61 | 5248 | India |
| Sanath Jayasuriya | 59 | 6973 | Sri Lanka / Asian XI |
| Ricky Ponting | 58 | 9776 | Australia / ICC World XI |
| Wasim Akram | 57 | 2898 | Pakistan |
| Imran Khan | 55 | 3807 | Pakistan |
| Craig McMillan | 54 | 3116 | New Zealand |
| Sourav Ganguly | 52 | 6581 | India / Asian XI |
| Shahid Afridi | 50 | 1683 | Pakistan / ICC World XI |
| Javed Miandad | 48 | 8832 | Pakistan |
| Aravinda de Silva | 48 | 6361 | Sri Lanka |
| Inzamam-ul-Haq | 48 | 8830 | Pakistan / Asian XI |
| Sachin Tendulkar | 47 | 11782 | India |
| Herschelle Gibbs | 47 | 6167 | South Africa |
| Mohammad Yousuf | 47 | 6770 | Pakistan / Asian XI |
| Virender Sehwag | 44 | 4441 | India / Asian XI |
| Marcus Trescothick | 42 | 5825 | England |
| Mark Waugh | 41 | 8029 | Australia |
| Arjuna Ranatunga | 40 | 5105 | Sri Lanka |
| Justin Langer | 40 | 7696 | Australia |
| Nathan Astle | 39 | 4702 | New Zealand |
| Kevin Pietersen | 39 | 3120 | England / ICC World XI |
| Navjot Sidhu | 38 | 3202 | India |
| Chris Gayle | 38 | 4658 | West Indies / ICC World XI |
| Shane Warne | 37 | 3154 | Australia / ICC World XI |
| Mahela Jayawardene | 37 | 7271 | Sri Lanka / Asian XI |
| Michael Holding | 36 | 910 | West Indies |
| Shaun Pollock | 35 | 3781 | South Africa / ICC World XI |
| Mohammad Rafique | 34 | 1059 | Bangladesh |
| John Reid | 33 | 3428 | New Zealand |
| Sir Richard Hadlee | 33 | 3124 | New Zealand |
| Hansie Cronje | 33 | 3714 | South Africa |
| Garry Sobers | 32 | 8032 | West Indies |
| Michael Slater | 30 | 5312 | Australia |
| Keith Miller | 28 | 2958 | Australia |
| Lance Cairns | 28 | 928 | New Zealand |
| Allan Border | 28 | 11174 | Australia |
| Wally Hammond | 27 | 7249 | England |
| Ken Barrington | 27 | 6806 | England |
| Wasim Raja | 27 | 2821 | Pakistan |