The most difficult thing to articulate.
The most difficult thing to articulate.
That was amazing.
Jesus brings life eternal
remembering the life of Phillip 'The Prince' Hughes
It is a horrible and insidious condition, and traversing it is a truly harrowing experience. Uppercut's link is fantastic though.
Kills too - had to spend the day before New Years Eve in ICU at the local hospital watching a friend of mine from Uni slip away - he had depression, which led to alcoholism, which led to malnutrition which led to multiple organ failure - bloke was a couple of years younger than me yet he looked at least 90 - it wasn't tragic or horrific - just so very sad
Last edited by Samuel_Vimes; 22-01-2015 at 03:35 PM. Reason: borken link
A follower of the schools of Machiavelli, Bentham, Locke, Hobbes, Sutcliffe, Bradman, Lindwall, Miller, Hassett and Benaud
Member of ESAS, JMAS, DMAS, FRAS and RTDAS
when you're winning, you have friends
scores and dozens, real friends
when you're winning, never lonely
when you keep winning
Fish are always deadset before the dawn
Fred Spofforth, 'The Demon Speaks'The figures Sir Home Hordon has shown me of what Grace did in matches against me, 37 innings, 1042 runs, 28.16 average, considerably less than his general average, hears out my theory that I never had any particular difficulty in getting him out. I clean bowled him seven times, ACM Croome says that WG told him that on any wicket he never knew when I should bowl him. This may have been due in part to my artfulness......
Psychology doesn't even have a decent definition for 'choice', let alone the cascading series of decisions which influence whatever definition of choice you care to use. And, of course, it all changes quickly when you take into account the possibility of a psychological illness such as depression. For an illness where the study of it tends to be heavily in favour of population-based methods, it has a lot of individual differences we don't (read: can't yet) allow for for. So all I'm doing is handing out sticks.
Last edited by Top_Cat; 02-03-2015 at 04:01 AM.
There's a somewhat intriguing theory that some depressions are caused or partly caused by some type of auto-immune response.
It's interesting as a lot of the cytokine profiles are similar to those seen in MS patients.
e.g. there are few of these types of meta studies around where they look at cytokine profiles and compare depression and bipolar disorder to inflammation.
If course it's all a bit simplistic when cytokines are labeled as either inflammatory or anti-inflammatory, and there's no real localisation data or anything like that and no identified mechanism, but it is a nice thought. The circumstantial evidence is that anti-inflammatory medication seems be effective in combating depression.
It is an extremely difficult thing to test though. I don't know if there's ever going to be a mouse model for bipolar disorder, for example.
Dunno if you accidentally linked to the wrong paper but that's not a meta-analysis. Was part of a special issue for that journal of psych disorders, basically a non-systematic lit review.
Interesting idea, but, and extends on the relatively new idea of simple, long-established pharmaceuticals being re-purposed (e.g. take a tablet of Aspirin every day to prevent heart attacks). Extending that into mental health is, obviously, an altogether different beast.
Last edited by Top_Cat; 02-03-2015 at 08:11 AM.
Immunology is pretty easy to make wide-sweeping theories about in that you can put all sorts of gene pathways, receptors, transcription factors, cytokines, hormones etc into different categories and then postulate some broad mechanism of action. Possibly people need to get systems biology more functional before we can get near figuring out whether these theories are even possible, let alone actually occur.
Still, they're fun to think about.
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