I think we had a fictional villains battle before, but it didn't get finished and I'm limiting it to cartoon characters. You can include villains from the newer sort of 3D animated movies, doesn't worry me much there.
Three nominations each, no need for a second. If possible, please put the show they are from:
Dick Dastardly (Wacky Races)
Verminous Skumm (Captain Planet and the Planeteers)
M. Bison (Street Fighter: The Animated Series)